A revolution in gene medicine: scientists have developed a method for safely delivering DNA

Scientists from the University of Pennsylvania have made a major breakthrough in the field of gene therapy, creating a method for safely delivering DNA to cells using lipid nanoparticles. This new technology opens up new possibilities in the treatment of serious diseases such as diabetes, cancer and heart disease.

A major problem in gene therapy has been solved

Although DNA-based therapies have been discussed for many years, their practical application has faced a number of problems. Previously, introducing DNA into cells would cause a destructive immune response, which could have serious effects on the body. However, the new lipid nanoparticle technology has solved this problem.

The system with nitroleic acid inhibited the inflammatory process in cells and showed 100% tolerance in tests on mice. This confirms the safety of the new method.

DNA and mRNA: the main differences

mRNA vaccines have become widespread during the COVID-19 pandemic and have been used to provide very rapid protection to the body. However, mRNA is stored in the body for only a few hours or days. DNA, on the other hand, can remain active for up to six months, which is important in the treatment of chronic diseases.

The new lipid nanoparticle system works in a “container” way, like mRNA vaccines, that is, therapeutic DNA is loaded into particles. At the same time, nitroleic acid, which blocks the STING pathway, controls the immune response of cells and prevents the body from overreacting to foreign genetic material.

What does the new technology open up?

The new gene therapy method has a number of advantages:

• Prevents immune system reaction – foreign DNA is safely accepted by the body.
  
• Long-term effect – therapeutic DNA remains active in the body for up to six months.
  
• New treatment options – innovative approaches to treating diabetes, cancer and heart disease will emerge.
  
• No need for viruses – instead of viruses, lipid nanoparticles are used in gene therapy.
  

Next steps

Scientists from the University of Pennsylvania now plan to test this method on various tissues and disease models. If the method is proven effective, it will usher in a new era in the field of gene therapy. A safe and effective method of gene therapy has been created, without the risks associated with injections or viruses.

This discovery could revolutionize the future fight against genetic diseases, cancer, diabetes and other serious illnesses. A new era of gene therapy is beginning! Follow “Zamin” news on “Telegram”