Parkinson’s can now be diagnosed in living patients: a scientific breakthrough from Chinese researchers

Parkinson’s disease, one of the most severe and late-diagnosed brain diseases, is a major health concern. Millions of people around the world live with it, and currently, there is no known cure.

Today, however, there is promising scientific news — researchers from Fudan University and Shanghai University of Traditional Chinese Medicine have successfully developed special compounds that allow for early detection of Parkinson’s and similar neurological conditions.

This research was published in the journal Genomic Psychiatry and has been widely praised by the global medical community.

Previously, it could only be detected after death

Parkinson’s disease is associated with the accumulation of a harmful protein in the brain — α-synuclein. This protein damages neurons and disrupts their function.

Previously, α-synuclein could only be detected post-mortem, making early diagnosis and effective treatment nearly impossible.

Now, for the first time, analysis of the living brain is possible

Using a newly developed technology by Chinese scientists, it is now possible to detect the accumulation of α-synuclein in living patients. A special compound is introduced into the body, and changes in the brain are observed through PET scanning (positron emission tomography).

“This is a true breakthrough. For the first time, we can directly see the pathology in a living patient’s brain,” said Dr. Fang He from Huashan Hospital.

[18F]C05-05 — a new era in Parkinson’s diagnosis

One of the compounds, [18F]C05-05, has already been successfully tested in patients with symptoms of Parkinson’s and dementia.

This substance accumulates in the brain regions with high levels of α-synuclein and was found to correlate directly with the severity of symptoms.

Another compound helps differentiate diseases

Another substance, [18F]ACI-12589, proved effective in diagnosing multiple system atrophy, another brain disorder. It helps distinguish it from Parkinson’s, despite similar symptoms.

Researchers’ main goal: diagnose before irreversible damage occurs

“If we can detect Parkinson’s and similar neurodegenerative diseases before irreversible damage begins, it can change the lives of millions of people,” said lead researcher Dr. Yinfan He.

In conclusion...

This technology may become the next revolutionary step in medicine. Identifying Parkinson’s and related diseases before symptoms worsen could help protect the brain and preserve quality of life.

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