Japanese scientists are developing a drug that helps teeth regrow

A new drug developed by a team of scientists in Japan could revolutionize dentistry. This innovative development could replace artificial devices such as implants, dentures, and crowns and help natural teeth grow back.

At the Medical Research Institute of Kitano Hospital in Osaka, a team led by Dr. Katsu Takahashi has been studying factors that influence tooth development based on years of genetic research. In a scientific article published in 2021, they scientifically proved that it is possible to activate natural tooth growth by blocking a gene called USAG-1.

A drug that "awakens" teeth: how does it work?

The USAG-1 gene naturally slows down tooth growth. By blocking the activity of this gene, the created drug activates the BMP protein — one of the main factors that helps bone and tooth development. As a result, new teeth grow through a natural process.

Tests and initial results

Currently, the drug is in the first phase of clinical trials on humans. Healthy volunteers are being given low doses and reactions in the body are being monitored. Tests on animals have shown clear results - new and strong teeth have grown with the drug.

A source of hope for whom?

If the studies are successful, this drug will greatly help the following people:

• Children born with congenital hypodontia - a lack of natural teeth due to genetics.
• Those who have lost their teeth due to injury or infection.
• Those who have lost their natural teeth due to aging.

Great potential for medicine and the economy

Dr. Takahashi emphasizes that this drug creates great opportunities not only from a medical point of view, but also from an economic point of view. Given the high cost and painful procedures of implants and dentures, a drug that allows natural teeth to regrow could usher in a whole new era in dentistry.

The drug is expected to be introduced into mass clinical practice in the coming years. If all goes according to plan, the field of dentistry will witness another major breakthrough that will improve human life.