Scientists have identified 380 gene variants that determine the risk of developing cancer

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Scientists at Stanford University have identified 380 important genetic variants that significantly affect the development of cancer. The results of the study were published in the journal Nature Genetics.

Scientists explain that thousands of small changes in the DNA sequence of the human genome are associated with oncological diseases. However, it was not known which of these changes directly contribute to the uncontrolled growth of cancer cells.

To fill this gap in knowledge, scientists conducted the first large-scale analysis of these inherited genetic changes, called single nucleotide polymorphisms. The experiment collected genetic samples from millions of people diagnosed with one of the 13 most common types of cancer.

The study identified nearly 400 variants that play a role in activating cancer cells and supporting their growth.

The researchers noted that the study focused on DNA sequences inherited during pregnancy, rather than mutations that can accumulate during cell division or repair during development. This database of genetic variants could be used to predict cancer risk in the future. Follow “Zamin” news on “Telegram”