A new era in liver regeneration: affordable and effective hope with cellular coating

The liver is one of the most active and vital organs in the body. Its functions include filtering blood, removing harmful substances, and producing essential proteins and compounds, reports combio.org. However, despite any protection, the liver is also vulnerable to serious diseases and injuries.

For many years, transplantation was considered the only solution for severe liver diseases. The shortage of donor organs, as well as the extremely high cost and risk of surgery, often drove many patients to despair. For this reason, scientists have continued to look for alternative opportunities in cell therapy.

Recent research has identified the main problem: hepatic progenitor cells, which are capable of regenerating the liver, do not integrate well into the body and do not attach properly to the targeted area. Scientists at the University of Birmingham have tried to solve this problem with truly advanced technology. They proposed a method of coating the cells with sticky polysaccharides such as hyaluronic acid or alginate.

This biological coating ensures a strong fixation of the cells in the liver tissue, helps them bond well with endothelial cells, and as a result, increases the production of integrin proteins. This process is temporary, and after the cells adapt to their new environment, the coating disappears on its own.

Experiments on small liver models have shown that this method works effectively and safely. Scientists are now studying how this technology affects the human immune system and whether it can be applied to cells of other organs.

Dr. Maria Chiara Arno emphasizes that this achievement could open a new window of hope for patients who need donor organs: the method is cheaper, less traumatic, and could reach more people. The new coating technology is expected to become a revolution not only for the liver, but in the future for the heart, kidneys, and other vital organs in modern cell therapy.

Experts consider this direction one of the most important trends in the medicine of the future. After all, easy and affordable treatment for every person remains a great human dream. Read 'Zamin' on Telegram!